Spatial multi-omics analysis reveals vimentin-high macrophages-endothelial cells niche shapes CAFs heterogeneity in colorectal cancer metastasis
Mingzhou Li, Bingyu Xu, Jieqiong Wu, Zhengyu Zhang, Bingze Chen, Yujie Chen, Danyi Li, Xinrun Tu, Kexin Wang, Zhihan Yang, Yifang Li, Yin Tan, Jinghao Huang, Yunfei Ni, Zilong Chen, , Liang Li
The paper identifies a vimentin-high macrophages-endothelial niche that drives CAF heterogeneity in CRC metastasis, with distinct signaling pathways in primary tumors and liver metastases.
bioRxiv · Aug 27, 2026 · PreprintCancer Biology