Two pore domain THIK2 channel is involved in acute and chronic pain signal regulation
Nicolas Gilbert, Franck C. Chatelain, Solène Gibaud, Thomas Lorivel, Ying-Ling Shen, Marie‐Emmanuelle Kerros, Sylvain F. Feliciangeli, Frédéric FIORE, Chih‐Cheng Chen, Florian Lesage, Delphine Bichet
This study investigates the role of THIK2 channels in pain regulation through molecular, electrophysiological, and behavioral analyses in knock-out mice, revealing their involvement in limiting neuronal hyperexcitability and suggesting therapeutic potential for chronic pain.
bioRxiv · Aug 8, 2025 · PreprintNeuroscience