Frédéric FIORE

This study shows that gain- and loss-of-function mutations in KCNK9 cause perinatal lethality in mice, indicating BBS pathogenesis involves mechanisms beyond channel activity.

This study identifies MARK2 as a gatekeeper of CD28-dependent co-stimulation in T cells, showing it restricts metabolic and transcriptional programs normally driven by CD28.

This study shows that plasmacytoid dendritic cells (pDCs) and their interferons are dispensable or harmful in systemic and respiratory viral infections in mice.

This study investigates the role of THIK2 channels in pain regulation through molecular, electrophysiological, and behavioral analyses in knock-out mice, revealing their involvement in limiting neuronal hyperexcitability and suggesting therapeutic potential for chronic pain.

The paper shows that mucosal B cell memory selection diverges between lungs and gut, favoring MBCs and PCs respectively, driven by tissue-specific BCR isotype usage rather than affinity.

The paper shows that inducing telomerase in p21-positive cells in aging mice lungs reduces capillary rarefaction and improves lung function by promoting microvasculature regeneration.

This study shows that telomerase expression in old mice prevents emphysema by maintaining endothelial and AT2 cell populations through increased proliferation.