High-throughput TCRB enrichment sequencing of human cord blood exhibited a distinct fetal T cell repertoire in the third trimester of pregnancy
Yan Dong, Wei Chen, Jinmin Wang, Xiaolei Wu, Yangyu Zhao, Yuhang Cai, Yingxin Han, Yuqi Wang, Hongmei Li, Jie Qiao, Yuan Wei
This study analyzes the TCRB repertoire in human cord blood from 24-38 weeks gestation, finding fetal TCRB repertoires have lower diversity and shorter CDR3s compared to adults, with CDR3 length increasing with gestational age.
bioRxiv · Sep 8, 2022 · PreprintGenetics