Jie Qiao

This paper uses AI to engineer a more stable and pH-tolerant glucoamylase variant, achieving higher starch conversion without acidification.

CASPE is a lightweight platform for site-directed protein engineering that improves the identification of beneficial mutations for thermostability and pH tolerance.

This study reports cryo-EM structures of GGCX bound to VKDPs and vitamin K, revealing its dual-catalytic mechanism and disease-associated mutation clusters.

This paper introduces DECENT, a deep learning method to reconstruct embryonic copy number variations and reduce maternal DNA contamination in cfDNA from SECM, improving the accuracy of noninvasive preimplantation genetic testing.

The paper uses single oocyte full-length isoform sequencing to identify novel transcripts and show that transposable elements contribute to RNA isoform diversity and stability during oocyte maturation.

The paper identifies a mutation in PIEZO1 that abolishes mechanical activation but not chemical activation, showing a direct link between mechanosensitivity and fetal hydrops.

This paper presents a non-invasive preimplantation genetic testing method using spent embryo culture medium, achieving high accuracy for monogenic and polygenic disease detection without modifying IVF workflows.

This study develops ac4C LACE-seq to profile mRNA N4-acetylation in mouse oocytes and shows NAT10 is essential for ac4C modification, which enhances translation efficiency during meiotic maturation.

GametesOmics integrates multi-omics data from human and mouse gametogenesis to provide tools for analyzing gene expression, DNA methylation, and chromatin accessibility.

This study analyzes the TCRB repertoire in human cord blood from 24-38 weeks gestation, finding fetal TCRB repertoires have lower diversity and shorter CDR3s compared to adults, with CDR3 length increasing with gestational age.

This paper describes a method to generate blastocyst-like structures from human pluripotent stem cells and shows they resemble blastocysts in morphology and transcriptome.

This study develops a single-cell multiomics sequencing method to analyze epigenetic and transcriptional dynamics in mouse preimplantation embryos, revealing regulatory networks and lineage specification mechanisms.

This study uses single-cell RNA-seq to evaluate ACE2 expression in ovarian tissues across developmental stages, identifying high ACE2 expression in PGCs and COC and its potential role in SARS-CoV-2 infection risk.

This study investigates the epigenetic effects of prenatal testosterone transfer between opposite-sex twins using DNA methylation and histone modification data, finding distinct epigenetic signatures linked to cognition, nervous system, and immune responses.

The paper introduces GeACT, a genomic database for human mid-gestation fetus cells, linking gene expression to chromatin states and identifying key transcription factors.

This study shows CDC6 is essential for G2 arrest and regulates spindle assembly and metaphase-to-anaphase transition in mouse oocytes.

This study examines the epigenetic effects of assisted reproductive technologies on human offspring, finding that certain procedures introduce DNA methylation changes linked to long-term health risks.

This study profiles the transcriptomes of human oocytes and granulosa cells across folliculogenesis stages, identifying stage-specific genes, cell interactions, and differences from mouse oocytes.