Evaluation of harmonization methods to mitigate assay and cohort effects in plasma p-tau217
Vivian Z. Zhang, Pâmela C.L. Ferreira, Yiwen Dong, Davneet Singh Minhas, Guilherme Povala, Bruna Bellaver, Tharick Ali Pascoal, Xuemei Zeng, Thomas K. Karikari, Ann D. Cohen, Rebecca A. Deek, Qiong Wu, Dana Tudorascu
This study evaluates harmonization methods to reduce assay and cohort effects in plasma p-tau217 measurements across two cohorts, finding that quantile mapping is most effective.
bioRxiv · Jul 28, 2026 · PreprintNeuroscience