Author

Guilherme Povala

University of PittsburghORCID 0000-0002-2023-6569Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:batch correction / integration· 1 Research Focus:benchmarking· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

Eduardo Rigon ZimmeriD· 3 shared Marco Antônio De BastianiiD· 3 shared Tharick Ali PascoaliD· 3 shared Andrei BiegeriD· 2 shared Bruna BellaveriD· 2 shared Giordana Salvi de SouzaiD· 2 shared Pâmela C.L. FerreiraiD· 2 shared Pedro Rosa‐NetoiD· 2 shared

Activity by Year

2023-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersNeuroscience

Eduardo Rigon ZimmerORCID

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4 papers

Recent·Most cited

Metabolic brain network reorganization precedes clinical conversion in Alzheimer's disease

Christian Limberger, Guilherme Garcia Schu, Giordana Salvi de Souza, Marco Antônio De Bastiani, Andrei Bieger, Gabriel Bueno Martins, Giovanna Carello‐Collar, Guilherme Povala, Luiza Santos Machado, Thomas Hugentobler Schlickmann, Alzheimer’s Disease Neuroimaging Initiative, Tharick Ali Pascoal, Pedro Rosa‐Neto, Débora G. de Souza, Eduardo Rigon Zimmer

The paper identifies hyperconnected metabolic networks in preclinical Alzheimer's converters using FDG-PET data, showing network reorganization precedes clinical conversion.

bioRxiv · Aug 7, 2026 · PreprintNeuroscience

Sources of Variability in Normative Cerebral FDG-PET imaging

Giordana Salvi de Souza, Guilherme Povala, Guilherme G. Schu Peixoto, Artur Martins Coutinho, Andrei Bieger, Mateus Rozalem Aranha, Marco Antônio De Bastiani, Eduardo Rigon Zimmer, Wyllians Vendramini Borelli, Laura Willers Souza

The paper investigates variability in FDG-PET imaging due to scanner manufacturer, reference region, age, and sex, and generates covariate-adjusted normative data.

bioRxiv · Aug 5, 2026 · PreprintNeuroscience

Evaluation of harmonization methods to mitigate assay and cohort effects in plasma p-tau217

Vivian Z. Zhang, Pâmela C.L. Ferreira, Yiwen Dong, Davneet Singh Minhas, Guilherme Povala, Bruna Bellaver, Tharick Ali Pascoal, Xuemei Zeng, Thomas K. Karikari, Ann D. Cohen, Rebecca A. Deek, Qiong Wu, Dana Tudorascu

This study evaluates harmonization methods to reduce assay and cohort effects in plasma p-tau217 measurements across two cohorts, finding that quantile mapping is most effective.

bioRxiv · Jul 28, 2026 · PreprintNeuroscience

Hippocampal GFAP-positive astrocyte responses to amyloid and tau pathologies

Marco Antônio De Bastiani, Bruna Bellaver, Wagner Scheeren Brum, Débora Guerini de Souza, Pâmela C.L. Ferreira, Andréia Silva da Rocha, Guilherme Povala, João Pedro Ferrari‐Souza, Andréa Lessa Benedet, Nicholas James Ashton, Thomas K. Karikari, Henrik Zetterberg, Kaj Blennow, Pedro Rosa‐Neto, Tharick Ali Pascoal, , the Alzheimer’s Disease Neuroimaging Initiative

The paper investigates GFAP-positive astrocyte responses to amyloid-beta and tau pathologies in humans and mouse models, finding distinct molecular signatures associated with each pathology.

Brain, Behavior, and Immunity · May 1, 2023Peer-reviewedNeuroscience