Serum Amyloid P Secreted by Bone Marrow Adipocytes Drives Skeletal Amyloidosis
Surendra Kumar, Kangping Song, Jiekang Wang, Meghraj Singh Baghel, Yixiang Zeng, Ke Shen, Junying Zheng, Janet Crane, Shadpour Demehri, Peisong Gao, Amit Jain, Richard L. Skolasky, Philip C. Wong, Xu Cao, Mei Wan
This study shows that senescent bone marrow adipocytes secrete SAP/PTX2, which promotes skeletal amyloidosis and bone loss in aging mice.
Nature Aging · Jul 29, 2025Peer-reviewedCell Biology