Author

Ke Shen

Peking UniversityORCID 0000-0003-2818-8124Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Cell Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Dubai LiiD· 2 shared Xiaoliang Sunney XieiD· 2 shared Xinyao WangiD· 2 shared Amit Jain· 1 shared Chen XieiD· 1 shared Chen XieiD· 1 shared Cheng LuoiD· 1 shared Fanchong JianiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiophysics

Dubai LiORCID

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3 papers

Recent·Most cited

Cell BiologyNature AgingPeer-reviewedJul 29, 2025

Serum Amyloid P Secreted by Bone Marrow Adipocytes Drives Skeletal Amyloidosis

Surendra Kumar, Kangping Song, Jiekang Wang…·Mei Wan

This study shows that senescent bone marrow adipocytes secrete SAP/PTX2, which promotes skeletal amyloidosis and bone loss in aging mice.

16 citationstop 5%

mouseexperimental assay

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BiophysicsProceedings of the National Academy of SciencesPeer-reviewedApr 30, 2025

Quantification and potential functional relevanceof binding cooperativity of adjacent transcriptionfactors on DNA

Xinyao Wang, Chen Xie, Ke Shen…·Xiaoliang Sunney Xie

This paper quantifies binding cooperativity between adjacent transcription factors on DNA and identifies its functional roles in gene regulation.

5 citations

ChIP-seqstatistical model

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GenomicsProceedings of the National Academy of SciencesPeer-reviewedDec 17, 2024

Human transcription factor combinations mapped by footprinting with deaminase

Runsheng He, Wenyang Dong, Zhi Wang…·Xiaoliang Sunney Xie

The paper introduces a method to map transcription factor binding sites genome-wide with single-base resolution and applies it to study cell-type-specific TF cooperativity in human tissues.

24 citations

humanDNA methylation

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