Know Your Alphabet: Conformational Noise, Latent-Space Encodings, and the Future of Structural Phylogenetics
Madeline Schmid, Yixiao Liu, Ashar J. Malik, David Benjamin Ascher
The paper introduces a metric to quantify conformational noise in structural alphabets and shows its impact on phylogenetic inference using NMR ensembles and molecular dynamics simulations.
bioRxiv · May 9, 2026 · PreprintBioinformatics