Author

Yizhen Zhong

Northwestern University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 3 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Organism:human· 4 Approach:statistical model· 4 Research Focus:eQTL / molecular QTL mapping· 3 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Minoli A. PereraiD· 4 shared Cristina AlarcóniD· 3 shared Tanima DeiD· 2 shared Anmol SinghiD· 1 shared C. Sehwan ParkiD· 1 shared Carolina Clark· 1 shared Eric R. GamazoniD· 1 shared Guang YangiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersGenomics

Minoli A. PereraORCID

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4 papers

Recent·Most cited

MeQTL Mapping in African American Hepatocytes Reveals Shared Genetic Regulators of DNA Methylation and Gene Expression

Kathryn Carver, Carolina Clark, Yizhen Zhong, Guang Yang, Mrinal Mishra, Cristina Alarcón, Minoli A. Perera

The paper identifies meQTLs in African American hepatocytes, finds colocalization with eQTLs, and shows genetic differences in methylation regulation between African and European ancestry.

bioRxiv · Jan 23, 2025 · PreprintGenomics

Leverage drug perturbation to reveal genetic regulators of hepatic gene expression in African Americans

Yizhen Zhong, Tanima De, Juan Avitia, Cristina Alarcón, Minoli A. Perera

The paper uses drug perturbation in African American hepatocytes to identify drug response eQTLs (reQTLs) and find genetic regulators of hepatic gene expression.

bioRxiv · Apr 27, 2022 · PreprintGenomics

Incorporation of DNA methylation into eQTL mapping in African Americans.

Anmol Singh, Yizhen Zhong, Layan Nahlawi, C. Sehwan Park, Tanima De, Cristina Alarcón, Minoli A. Perera

This study incorporates DNA methylation into eQTL mapping in African American hepatocytes, revealing new eQTLs and eGenes and suggesting DNA methylation modulates SNP-gene associations.

Pacific Symposium on Biocomputing (PSB) · Nov 1, 2020Peer-reviewedGenomics

On Using Local Ancestry to Characterize the Genetic Architecture of Human Phenotypes: Genetic Regulation of Gene Expression in Multiethnic or Admixed Populations as a Model

Yizhen Zhong, Minoli A. Perera, Eric R. Gamazon

This study develops a statistical framework using local ancestry to improve eQTL mapping and heritability estimation in admixed populations, showing improved accuracy and error control.

The American Journal of Human Genetics · May 16, 2019Peer-reviewedBioinformatics