Minoli A. Perera

This study improves proteome-wide association study results by using multi-ancestry data, finding more protein-phenotype associations and better prediction models.

The paper identifies meQTLs in African American hepatocytes, finds colocalization with eQTLs, and shows genetic differences in methylation regulation between African and European ancestry.

The paper uses drug perturbation in African American hepatocytes to identify drug response eQTLs (reQTLs) and find genetic regulators of hepatic gene expression.

This paper identifies a genetic variant associated with primary non-response to anti-TNFα therapy in IBD patients and links it to increased TNF secretion through autophagy mechanisms.

This study incorporates DNA methylation into eQTL mapping in African American hepatocytes, revealing new eQTLs and eGenes and suggesting DNA methylation modulates SNP-gene associations.

This study develops a statistical framework using local ancestry to improve eQTL mapping and heritability estimation in admixed populations, showing improved accuracy and error control.

The paper identifies genes and methylation regions associated with West African ancestry in African Americans and links them to disease and drug response pathways.