Genetic & Genomic MedicinemedRxivPreprint
Local ancestry informed GWAS of warfarin dose requirement in African Americans identifies a novel CYP2C19 splice QTL
Anmol Singh, Cristina Alarcón, Edith A. Nutescu…·Minoli A. Perera
Author
Cristina Alarcón
Northwestern UniversityORCID 0009-0003-0872-9904Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2020-2025 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 23 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship4 papers
Recent·Most cited
- GenomicsbioRxivPreprint
MeQTL Mapping in African American Hepatocytes Reveals Shared Genetic Regulators of DNA Methylation and Gene Expression
Kathryn Carver, Carolina Clark, Yizhen Zhong…·Minoli A. Perera
The paper identifies meQTLs in African American hepatocytes, finds colocalization with eQTLs, and shows genetic differences in methylation regulation between African and European ancestry.
DOI 10.1101/2025.01.23.634506 - GenomicsbioRxivPreprint
Leverage drug perturbation to reveal genetic regulators of hepatic gene expression in African Americans
Yizhen Zhong, Tanima De, Juan Avitia…·Minoli A. Perera
The paper uses drug perturbation in African American hepatocytes to identify drug response eQTLs (reQTLs) and find genetic regulators of hepatic gene expression.
DOI 10.1101/2022.04.27.489765 - GenomicsPacific Symposium on Biocomputing (PSB)Peer-reviewed
Incorporation of DNA methylation into eQTL mapping in African Americans.
Anmol Singh, Yizhen Zhong, Layan Nahlawi…·Minoli A. Perera
This study incorporates DNA methylation into eQTL mapping in African American hepatocytes, revealing new eQTLs and eGenes and suggesting DNA methylation modulates SNP-gene associations.
3 citations