Tirzepatide attenuates dopamine reward signaling and suppresses alcohol drinking and relapse-like behaviors in rodents
Christian E. Edvardsson, Louise Adermark, Sam Gottlieb, Safana Alfreji, Thaynnam Arcebispo Emous, Yomna Gouda, Annika Thorsell, Milica Vujičić, Cajsa Aranäs, Anna Benrick, Ingrid Wernstedt Asterholm, Marcelo F. Lopez, Howard C. Becker, Elisabet Jerlhag
This study shows tirzepatide reduces alcohol consumption and relapse-like behaviors in rodents by affecting reward systems and metabolic parameters.
bioRxiv · Aug 26, 2025 · PreprintNeuroscience