DNA methylation landscapes of matched primary and recurrent high grade serous ovarian cancers are preserved throughout disease progression and chemoresistance.
Nicole Gull, Michelle R. Jones, Pei-Chen Peng, Simon G. Coetzee, Tiago C. Silva, Jasmine Plummer, Alberto Luiz P. Reyes, Brian D Davis, Stephanie Chen, Kate Lawrenson, Jenny Lester, Christine Walsh, B.J. Rimel, Andrew John Li, Ilana A. Cass, , Simon A. Gayther
This study shows that DNA methylation and gene expression patterns are preserved in recurrent high grade serous ovarian cancers, with BRCA1/2 carriers showing more shared methylation changes and improved survival.
bioRxiv · Aug 25, 2020 · PreprintGenomics