A brown fat-enriched adipokine, ASRA, is a leptin receptor antagonist that stimulates appetite
Lei Huang, Pengpeng Liu, Yong Du, J. Fernando Bazán, Dongning Pan, Qingbo Chen, Alexandra Lee, Vijaya S.R. Kola, Scot A. Wolfe, Yong‐Xu Wang
This study identifies ASRA as a leptin receptor antagonist that stimulates appetite and contributes to obesity by counteracting leptin signaling.
bioRxiv · Sep 12, 2023 · PreprintMolecular Biology