Author

Yong-Jie Zhang

Mayo Clinic

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Assay:proteomics· 1

Frequent Co-Authors

Leonard PetrucelliiD· 2 shared Adrian M. IsaacsiD· 1 shared Ahad A. RahimiD· 1 shared Alessia Fisher· 1 shared Alexander J. CammackiD· 1 shared Alexander McGowniD· 1 shared Alla MikheenkoiD· 1 shared Alyssa N. CoyneiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersNeuroscience

Leonard PetrucelliORCID

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2 papers

Recent·Most cited

NeuroscienceNature CommunicationsPeer-reviewedJan 8, 2025

Dual-targeting CRISPR-CasRx reduces C9orf72 ALS/FTD sense and antisense repeat RNAs in vitro and in vivo

Liam Kempthorne, Deniz Vaizoglu, Alexander J. Cammack…·Adrian M. Isaacs

This study demonstrates that CRISPR-CasRx reduces C9orf72 repeat RNAs and DPRs in vitro and in vivo, suggesting its therapeutic potential for ALS/FTD.

27 citationstop 1%

humanmouse

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NeuroscienceProceedings of the National Academy of SciencesPeer-reviewedDec 1, 2022

Comprehensive preclinical evaluation of human-derived anti-poly-GA antibodies in cellular and animal models of C9ORF72 disease

Mélanie Jambeau, Kevin D. Meyer, Marián Hruška-Plocháň…·Clotilde Lagier‐Tourenne

This study evaluates human-derived anti-poly-GA antibodies in cellular and animal models of C9ORF72 disease, showing mixed effects on poly-GA levels and disease progression.

12 citations

humanmouse

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