Progesterone is an Inducement of Heritable Pulmonary Arterial Hypertension with BMPR2 Mutation
Weiping Hu, Si-Jin Zhang, Yongjie Ding, Jie Fang, Ling Zhou, Simin Xie, Xiao Ge, Lijun Fu, Qing Yun Li, Jieming Qu, Shanqun Li, Dong Liu
The paper investigates how progesterone induces heritable pulmonary arterial hypertension in BMPR2 mutation carriers, showing it promotes PASMC proliferation via ERK pathway activation.
bioRxiv · Apr 21, 2023 · PreprintMolecular Biology