TIGIT-NECTIN2/3 signaling preserves ignorant CD8⁺ T cells for favorable immune checkpoint outcomes in HBV-related hepatocellular carcinoma
Pei-Ching Chang, Zhi-Chen Yan, Yung-Chih Hong, YU Kai-ting, Tze-Yun Hu, Tze-Yun Hu, Chen-Ching Lin, Tai‐Ming Ko, Jinn‐Moon Yang, Muh‐Hwa Yang, Chunying Wu, Jiunn-Chang Lin, Yan‐Hwa Wu Lee
This study identifies TIGIT-NECTIN2/3 signaling as a mechanism preserving ignorant CD8⁺ T cells in HBV-related HCC, enhancing immune checkpoint inhibitor efficacy.
bioRxiv · May 8, 2026 · PreprintImmunology