Jinn‐Moon Yang

TIGIT-NECTIN2/3 signaling preserves ignorant CD8⁺ T cells for favorable immune checkpoint outcomes in HBV-related hepatocellular carcinoma

This study identifies TIGIT-NECTIN2/3 signaling as a mechanism preserving ignorant CD8⁺ T cells in HBV-related HCC, enhancing immune checkpoint inhibitor efficacy.

Integrating Drug-like Moieties and Binding Site Evolution for Kinase Inhibitor Prediction Using Ensemble Learning Models

The paper presents an ensemble learning model that integrates chemical and protein features to predict selective kinase inhibitors, achieving 93.6% accuracy on an independent test set.

Encoding Drug-Target-Pathway-Disease profiles for Drug-Cancer Association Prediction using Graph Transformer-Convolution Networks

The paper proposes a Graph Transformer-Convolution Network (GTCN) to predict drug-cancer associations by integrating heterogeneous biological data and enhancing interpretability.

Expanding Chemical Space: Developing a Compound Generative Pre-trained Transformer for De Novo Drug Design

This paper develops a compound generative pre-trained transformer model trained on 200 million compounds to generate chemically valid and novel drug-like molecules with high novelty.

Off-target prediction of SGLT2 inhibitors: an integrative bioinformatics approach to uncover structural mechanisms

This paper predicts off-target proteins of SGLT2 inhibitors using a bioinformatics approach, identifying structural features that guide binding and drug specificity.

A single-gene-based AI model to identify core and context-specific essential genes by biological interpretation from pooled genome-wide CRISPR and omics data

The paper develops an AI model to identify core and context-specific essential genes using CRISPR and omics data, finding 3,213 pan-cancer CEGs with 60% overlap to prior studies.

miR6236, a microRNA suppressed by the anisotropic surface topography, regulates neuronal development and regeneration.

This study identifies miR6236 as a microRNA suppressed by anisotropic nanodiamond surfaces that regulates neuronal development and regeneration.