EphB6 regulates social behavior through gut microbiota-mediated vitamin B6 metabolism and excitation/inhibition balance of medial prefrontal cortex in mice
Ying Li, Zheng-Yi Luo, Yu-Ying Hu, Yue-Wei Bi, Jian‐Ming Yang, Ming-An Liu, Wen-Jun Zou, Li Shi, Tong Shen, Shu-Ji Li, Lang Huang, Aijun Zhou, Yunlong Song, Tianming Gao, Jianming Li
This study shows that EphB6 deletion in mice disrupts gut microbiota, leading to autism-like behaviors through vitamin B6 metabolism and E/I imbalance in the medial prefrontal cortex.
bioRxiv · Sep 30, 2019 · PreprintNeuroscience