Tong Shen

The paper shows that dopamine dips during unrewarded actions increase punishment-resistant reward seeking in female mice, with optogenetic mimicry accelerating this behavior in both sexes.

The paper uses machine learning to analyze spatial lipidomic changes in mouse lungs exposed to allergens and ozone, revealing sex-specific lipid distribution differences.

The paper improves compound identification and inter-laboratory reproducibility in untargeted lipidomics using harmonized methods and spectral analysis.

This study shows that EphB6 deletion in mice disrupts gut microbiota, leading to autism-like behaviors through vitamin B6 metabolism and E/I imbalance in the medial prefrontal cortex.

The paper provides a metabolomics dataset from 30 mouse gene knockouts and wildtypes, identifying 832 metabolites across multiple analytical methods.