Interplay between mosaic chromosomal alterations and polygenic risk score increases risk of non-small cell lung cancer
Na Qin, Congcong Chen, Yang Liu, Su Liu, Yuan Xie, Xianfeng Xu, Jun Ying Zhou, Juncheng Dai, Guangfu Jin, Hongxia Ma, Cheng Wang, Hongbing Shen, Zhibin Hu
The paper examines the association between mosaic chromosomal alterations and polygenic risk scores in NSCLC risk, finding that mosaic loss increases risk, especially in high genetic risk individuals.
medRxiv · Apr 13, 2022 · PreprintGenetic & Genomic Medicine