TDP-43 proteinopathy impairs neuronal mRNP granule mediated postsynaptic local translation and mRNA metabolism
Chia‐En Wong, Lee‐Way Jin, Yuan-Ping Chu, Wei‐Yen Wei, Pei‐Chuan Ho, Kuen‐Jer Tsai
This study shows TDP-43 localizes to postsynaptic mRNP granules and impairs their dynamics and mRNA metabolism in neurodegenerative disease models.
Theranostics · Oct 28, 2020Peer-reviewedNeuroscience