Lee‐Way Jin

This paper develops a deep-learning method to segment neurofibrillary tangles from brain tissue images using manual annotations, achieving high accuracy and scalability.

This study investigates how O-GlcNAcylation affects Tau aggregation and toxicity in Alzheimer's Disease, showing reduced seeding and toxicity in O-GlcNAcylated Tau.

This study identifies L-fucose as a monosaccharide neuromodulator that enhances synaptic function and mitigates Alzheimer's disease symptoms in mice.

This study identifies genetic risk factors for FTLD-TDP subtypes using whole-genome sequencing and meta-analysis across multiple cohorts.

This study identifies differentially expressed genes and pathways in Alzheimer's disease brain tissue from African American donors, highlighting potential targets for treatment.

This paper shows that age-related memory CD8 T cells drive AD-like neurodegeneration upstream of Aβ/pTau in mice and are elevated in human AD patients.

The paper analyzes bulk RNA-seq data from diverse ethnic groups to identify differentially expressed genes and pathways in Alzheimer's Disease, highlighting cross-ethnic and ethnic-specific findings.

The paper identifies six genetic loci associated with Alzheimer's disease in Hispanics, showing both genetic and epigenetic risks, with some downstream effects on mRNA expression being ethnicity-specific.

This study identifies blood-based biomarkers associated with Alzheimer's disease genetic risk variants in a large cohort of healthy adults, showing effects from early adulthood and sex-specific patterns.

This study shows TDP-43 localizes to postsynaptic mRNP granules and impairs their dynamics and mRNA metabolism in neurodegenerative disease models.

This study shows that inhibiting ENT1 with J4 reduces Tau-mediated neurodegeneration in a mouse model by improving energy homeostasis and mitigating immune responses.