Optic nerve regeneration requires the intracellular domain of LIFRa/CD118
Qian Jiang, Cong Wang, Yuerong Ren, Peiyun Duan, Ke tian, Xiangwei Duan, Binghan Cai, Changzhong Xu, Jian Li, Larry I. Benowitz, Ningli Wang, Bing Jiang, Lili Xie
This study identifies the intracellular domain of LIFR/CD118 as essential for optic nerve regeneration in mature RGCs, independent of LIF and other therapies.
bioRxiv · Oct 14, 2025 · PreprintNeuroscience