Human fibroblasts from aged individuals exhibit chromosomal instability through replication stress caused by oxidative stress
Kailin Zhu, Guan Chen, Yueyi Ren, Kenji Iemura, Kozo Tanaka
This study shows that human fibroblasts from aged individuals exhibit chromosomal instability due to oxidative stress-induced replication stress, similar to findings in aged mouse fibroblasts.
npj Aging · Nov 25, 2025Peer-reviewedCell Biology