Geometric Fragility in Alzheimer's Disease: Probing the Loss of Hippocampal Hierarchical Abstraction via Contrastive Point Cloud Modeling
Yiquan Wang, Yuhan Chang, Jialin Zhang, Minnuo Cai, Jiayao Yan, Hongtian Zhao, the Frontotemporal Lobar Degeneration Neuroimaging Initiative
This study uses contrastive point cloud modeling to show that Alzheimer's disease involves a loss of hippocampal hierarchical abstraction, revealing a linear geometric degradation correlated with cognitive decline.
bioRxiv · Feb 3, 2026 · PreprintNeuroscience