Minnuo Cai

This paper decodes multi-state conformational heterogeneity from crystallographic B-factors using sequence context, introducing BFC to improve accuracy and utility in structural biology.

This paper shows that protein language models like ESM-2 encode evolutionary grammar rather than three-dimensional geometry, conflate topological and thermodynamic phases, and require explicit physical constraints for accurate modeling.

This study uses contrastive point cloud modeling to show that Alzheimer's disease involves a loss of hippocampal hierarchical abstraction, revealing a linear geometric degradation correlated with cognitive decline.

This paper explores using 2D spectrograms generated from amino acid sequences (sonification) for protein function prediction, showing improved performance over traditional methods.