Author

Jiayao Yan

Xinjiang UniversityORCID 0009-0006-6715-206XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Approach:contrastive learning· 1 Research Focus:dimensionality reduction· 1 Organism:human· 1 Assay:spatial transcriptomics· 1 Research Focus:trajectory inference· 1

Frequent Co-Authors

Hongtian Zhao· 1 shared Jialin Zhang· 1 shared Minnuo CaiiD· 1 shared the Frontotemporal Lobar Degeneration Neuroimaging Initiative· 1 shared Yiquan WangiD· 1 shared Yuhan Chang· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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1 shared paperNeuroscience

Hongtian Zhao

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1 paper

Recent·Most cited

NeurosciencebioRxivPreprintFeb 3, 2026

Geometric Fragility in Alzheimer's Disease: Probing the Loss of Hippocampal Hierarchical Abstraction via Contrastive Point Cloud Modeling

Yiquan Wang, Yuhan Chang, Jialin Zhang…·the Frontotemporal Lobar Degeneration Neuroimaging Initiative

This study uses contrastive point cloud modeling to show that Alzheimer's disease involves a loss of hippocampal hierarchical abstraction, revealing a linear geometric degradation correlated with cognitive decline.

DOI 10.64898/2026.01.31.702997

humanspatial transcriptomics

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