YAP1-2α heterodimerization with TAZ promotes cancer aggressiveness through BRD4-dependent liquid-liquid phase separation at super-enhancers
Takuya Ooki, Takeru Hayashi, Yui Yamamoto, Masanori Hatakeyama
This study shows YAP1-2α heterodimerization with TAZ promotes cancer aggressiveness via BRD4-dependent LLPS at super-enhancers, identifying it as a therapeutic target.
bioRxiv · Jan 28, 2025 · PreprintCancer Biology