Molecular Crowding-Driven Nucleosome Interactions Revealed Through Single-Molecule Optical Tweezers
T. Sunami, Amarjeet Kumar, Shoko Sato, Yuko Hara, Hitoshi Kurumizaka, Hidetoshi Kono
This study uses single-molecule optical tweezers to show that high-concentration, high-molecular-weight PEG promotes chromatin compaction by enhancing internucleosomal interactions.
bioRxiv · Jan 21, 2026 · PreprintBiophysics