Hidetoshi Kono

This study uses MD simulations to analyze how DNA intercalators affect DNA conformation, revealing distinct intercalation patterns and their impact on mechanical properties.

This paper reports cryo-EM structures of the HHV1 helicase-primase complex bound to DNA and inhibitors, revealing how these drugs block viral DNA replication by locking the helicase in an inactive conformation.

This study uses single-molecule optical tweezers to show that high-concentration, high-molecular-weight PEG promotes chromatin compaction by enhancing internucleosomal interactions.

HiC-SCA improves A/B compartment assignment from Hi-C data through spectral clustering with noise filtering and resolution selection, showing better consistency across datasets.