Macropinocytosis-Mediated Recyclable LYTACs (McR-TACs) for Membrane and Extracellular Protein Degradation
Peixin Liu, Yule Li, Yawen You, Yu Chen, Michelle Cai, Quanyin Hu
This paper develops McR-TACs, a recyclable LYTAC system that degrades cell membrane and extracellular proteins via macropinocytosis, independent of lysosome-shuttling receptors.
bioRxiv · Sep 8, 2025 · PreprintBiochemistry