Metformin lowers HMGA1a and RBM3 protein in breast cancer cells, and its effect on ESR1 splicing depends on cell density and exposure time
Yoshihiro Harada, Tomoko Tanaka, Yuriko Hamaguchi, Yuta Horita, Hiroyoshi Harada, Masayoshi Mori, Yusuke Murata, Kenji Ohe
This paper investigates how metformin affects ESR1 splicing in breast cancer cells, finding that its effect depends on cell density and exposure time, and that HMGA1a is unlikely to be the splicing factor responsible.
bioRxiv · Nov 5, 2026 · PreprintMolecular Biology