Kenji Ohe

Metformin lowers HMGA1a and RBM3 protein in breast cancer cells, and its effect on ESR1 splicing depends on cell density and exposure time

This paper investigates how metformin affects ESR1 splicing in breast cancer cells, finding that its effect depends on cell density and exposure time, and that HMGA1a is unlikely to be the splicing factor responsible.

Herboxidiene and EGFR expression in A172 glioblastoma cells

This study investigates how herboxidiene affects EGFR expression and proliferation in A172 glioblastoma cells, finding that it inhibits growth without causing intron 2 retention seen in lung adenocarcinoma cells.

SF3b inhibitors suppress proliferation of nonsmall cell lung cancer cells irrespective of EGFR mutation status

The paper tests SF3b inhibitors on NSCLC cells with different EGFR statuses, finding growth suppression regardless of EGFR mutation, suggesting a mechanism independent of EGFR kinase activity.

Sodium butyrate inhibits the proliferation of temozolomide-resistant glioblastoma (A172) and lung adenocarcinoma (A549) cells and biphasically regulates EGFR expression

Decoy and antisense RNA oligonucleotides targeting the EGFR exon 3 splice site suppress proliferation of A172 glioblastoma cells

The paper shows that decoy and antisense RNA oligonucleotides targeting EGFR exon 3 splice site reduce proliferation in A172 glioblastoma cells but not in A549 lung adenocarcinoma cells.