Yuta Horita

This paper investigates how metformin affects ESR1 splicing in breast cancer cells, finding that its effect depends on cell density and exposure time, and that HMGA1a is unlikely to be the splicing factor responsible.

This study investigates how herboxidiene affects EGFR expression and proliferation in A172 glioblastoma cells, finding that it inhibits growth without causing intron 2 retention seen in lung adenocarcinoma cells.

The paper tests SF3b inhibitors on NSCLC cells with different EGFR statuses, finding growth suppression regardless of EGFR mutation, suggesting a mechanism independent of EGFR kinase activity.

The paper shows that decoy and antisense RNA oligonucleotides targeting EGFR exon 3 splice site reduce proliferation in A172 glioblastoma cells but not in A549 lung adenocarcinoma cells.