5' UTR-mediated retention of eIF3 on 80S ribosomes promotes co-translational folding of ER membrane proteins
Baochun Han, Siqiong Zhang, Yurui Zhang, Binbin Yu, Weimin Lin, Yabin Cheng, Haoran Duan, Dieter A Wolf
The paper shows that 5' UTR binding sites for eIF3 on ER membrane protein mRNAs retain eIF3 on 80S ribosomes, promoting co-translational folding and preventing misfolding and sequestration into ER whorls.
Cell Reports · Dec 1, 2025Peer-reviewedCell Biology