De novo protein design enables targeting of intractable oncogenic interfaces
Varshika Ram Prakash, Yusuf Najy, Kalel Garrett, Brian F.P. Edwards, Benjamin L. Kidder
This paper introduces DesignForge, a de novo protein design framework that creates therapeutic protein binders targeting oncogenic PPIs, showing high structural confidence and hotspot engagement.
bioRxiv · Oct 22, 2025 · PreprintBioinformatics