Proteogenomic profiling of soft tissue leiomyosarcoma reveals distinct molecular subtypes with divergent outcomes and therapeutic vulnerabilities
Atsushi Tanaka, Makiko Ogawa, Yusuke Otani, Ronald C. Hendrickson, Zhuoning Li, Narasimhan P. Agaram, David S. Klimstra, Julia Y. Wang, Wenyi Wei, Michael H. A. Roehrl
This study identifies three proteogenomic subtypes of soft tissue leiomyosarcoma with distinct molecular features and clinical outcomes, suggesting potential therapeutic targets.
bioRxiv · Nov 19, 2025 · PreprintCancer Biology