Wenyi Wei

This study identifies BRD2 as a co-targetable vulnerability with PI3K/AKT inhibitors in breast cancer, showing that BRD2 phosphorylation is required for chromatin binding and that targeting BRD2 enhances drug efficacy.

The paper introduces dubTAGs, small molecules that stabilize proteins tagged with FKBP12F36V by recruiting deubiquitinases, enabling tunable and reversible control of protein levels.

The paper identifies protein interactors of COPD GWAS genes using AP-MS and network analysis, revealing a disease network module involving 8 proteins.

The paper identifies a new four-membered-ring chemotype that selectively binds OTUB1, expands its ligandable chemical space, and enables the development of next-generation DUBTACs.

This study identifies three proteogenomic subtypes of soft tissue leiomyosarcoma with distinct molecular features and clinical outcomes, suggesting potential therapeutic targets.

The paper identifies HHIP protein interactions in lung cells, revealing new connections to COPD GWAS genes and providing insights into COPD pathogenesis.

This study identifies Dab2 and FoxM1 as key regulators of endothelial dysfunction in diabetes, showing that restoring Dab2 improves angiogenesis and wound healing.

The paper identifies FBXO38 as a novel COPD susceptibility gene by analyzing genetically driven alternative splicing and finding a protective exon associated with COPD risk.