Lipogenic Lung Fibroblast-derived Extracellular Vesicles Mitigate Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease Pathologies through LAT1-mediated Alveolar Type II Cell Restoration
Shota Fujimoto, Yuta Hirano, Naoaki Watanabe, Sachi Matsubayashi, Shun Inukai, Saiko Nishioka, Masahiro Yoshida, Saburo Ito, Shunsuke Minagawa, Hiromichi Hara, Takashi Ohtsuka, Pattama Wiriyasermkul, Shushi Nagamori, Kazuyoshi Kuwano, Jun Araya, Yu Fujita
This study shows that lipogenic lung fibroblast-derived extracellular vesicles reduce COPD pathologies by restoring alveolar type II cells via LAT1-mediated mechanisms.
bioRxiv · Jun 17, 2024 · PreprintMolecular Biology