A novel uN2CpolyG Transgenic Mouse Model Recapitulates Multisystemic polyG Proteinopathy Pathology of Neuronal Intranuclear Inclusion Disease
Yalan Wan, Yilei Zheng, Chao Gao, Yuxuan Lu, Fuze Zheng, Zhen Yu, Jiaxin Wang, Biyu Yang, Jie Zheng, Yun Yuan, Daojun Hong, Nicolas Charlet‐Berguerand, Jiaxi Yu, Zhaoxia Wang, Jianwen Deng
This study develops a transgenic mouse model that recapitulates the multisystemic pathology of neuronal intranuclear inclusion disease through polyG protein aggregates.
bioRxiv · Feb 12, 2026 · PreprintAnimal Behavior & Cognition