Jie Zheng

FXR-mediated recruitment of PPP1CB suppresses SMAD2/3 phosphorylation to mitigate pulmonary fibrosis

This study identifies FXR as a suppressor of pulmonary fibrosis by interacting with PPP1CB to reduce SMAD2/3 phosphorylation, showing therapeutic potential with TERN101.

A novel AR molecular glue degrader via bivalent engagement of the N-terminal domain and RNF213-UBE2J2 complex

This paper introduces GZL626, a novel AR degrader that targets the N-terminal domain and RNF213-UBE2J2 complex, effectively degrading AR and AR-V7 and showing antitumor and antiviral activity.

Identification of SNARE Genes in Cucumber and the Role of CsSYP121 in Salt Stress Response

This study identifies SNARE genes in cucumber and shows that CsSYP121 enhances salt tolerance by improving K+/Na+ homeostasis and antioxidant capacity.

A novel uN2CpolyG Transgenic Mouse Model Recapitulates Multisystemic polyG Proteinopathy Pathology of Neuronal Intranuclear Inclusion Disease

This study develops a transgenic mouse model that recapitulates the multisystemic pathology of neuronal intranuclear inclusion disease through polyG protein aggregates.

SEA CDM: Study-Experiment-Assay Common Data Model and Databases for Cross-Domain Data Integration and Analysis

The paper introduces a common data model and databases for integrating heterogeneous biomedical data, enabling cross-domain analysis and revealing sex-specific immune response insights.

Targeting the host factor HGS-viral membrane protein interaction in coronavirus infection

This study identifies HGS as a host factor critical for coronavirus infection and discovers RTB as a broad-spectrum antiviral by disrupting HGS-M protein interaction.

Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitis

Cholesterol accumulation in hepatic lipid droplets drives inflammation and fibrosis in mouse and human MASH and is reversed by inhibiting cholesterol synthesis or knocking down Coasy or Hsd17b13.