Cancer BiologybioRxivPreprint
Integrated Molecular Profiling Studies to Characterize the Cellular Origins of High-Grade Serous Ovarian Cancer
Kate Lawrenson, Marcos A.S. Fonseca, Felipe Segato…·Houtan Noushmehr
The paper uses transcriptomic and epigenomic profiling to show that high-grade serous ovarian cancers predominantly originate from fallopian tube secretory epithelial cells, with distinct transcription factors driving tumorigenesis based on cell-of-origin.
DOI 10.1101/330597