Integrated Molecular Profiling Studies to Characterize the Cellular Origins of High-Grade Serous Ovarian Cancer
Kate Lawrenson, Marcos A.S. Fonseca, Felipe Segato, Janet M. Lee, Rosario I. Corona, Ji-Heui Seo, Simon Coetzee, Yvonne G. Lin, Tanja Pejovic, Paulette Mhawech-Fauceglia, Ronny Drapkin, Beth Y. Karlan, Dennis J. Hazelett, Matthew L. Freedman, Simon A. Gayther, Houtan Noushmehr
The paper uses transcriptomic and epigenomic profiling to show that high-grade serous ovarian cancers predominantly originate from fallopian tube secretory epithelial cells, with distinct transcription factors driving tumorigenesis based on cell-of-origin.
bioRxiv · May 25, 2018 · PreprintCancer Biology