Spatial transcriptomic analysis of muscle biopsy from treatment-naive juvenile dermatomyositis patients reveals mitochondrial abnormalities despite disease-related interferon driven signature
Aris E Syntakas, Melissa Kartawinata, Nia M.L. Evans, Huong D. Nguyen, Charalampia Papadopoulou, Muthana Al Obaidi, Clarissa Pilkington, Yvonne Glackin, Christopher B. Mahony, Adam P. Croft, Simon D. Eaton, Mario Cortina‐Borja, Olumide Kayode Ogunbiyi, Ashirwad Merve, Lucy R. Wedderburn, Meredyth Grace Llewellyn Wilkinson
This study uses spatial transcriptomics to show mitochondrial dysfunction in JDM muscle tissue, independent of interferon-driven inflammation.
Annals of the Rheumatic Diseases · Aug 9, 2025Peer-reviewedImmunology