Simon D. Eaton

This paper evaluates two cryopreservation strategies for amniotic fluid cells to improve organoid derivation efficiency and identifies an optimal freezing medium.

This study shows that mitochondrial pyruvate import in astrocytes is essential for maintaining neurotransmitter homeostasis and seizure resistance, rather than primarily for bioenergetic purposes.

This study compares AAV9 and AAV-F capsids for treating PDHD in mice, finding AAV-F improves survival and enzyme activity at lower doses but causes motor impairments.

The paper develops multi-regional gastric assembloids from patient-derived organoids to model parietal cell maturation and antral foveolar hyperplasia in genetic disorders.

This study identifies lipid dysregulation linked to mitochondrial dysfunction in Parkinson's Disease brain regions through multi-omics analysis of lipids, proteomics, and mitochondrial activity.

This study uses spatial transcriptomics to show mitochondrial dysfunction in JDM muscle tissue, independent of interferon-driven inflammation.

This paper investigates VEGF supplementation as a treatment for congenital diaphragmatic hernia (CDH)-associated lung abnormalities using an ex vivo model and nanoparticle-based delivery in vivo.

This study uses hiPSCs with SNCA mutations to identify early molecular events in synucleinopathy, showing protein aggregation precedes functional impairments in midbrain dopaminergic neurons.

This study shows that mRNA therapy restores ureagenesis and glutathione metabolism in ASL-deficient mice, correcting liver disease and neurocognitive impairments.

This study shows that activating autophagy via Beclin-1 improves biochemical and clinical outcomes in two types of urea cycle disorders.