Christopher B. Mahony

This study identifies two distinct Treg states in RA synovial tissues using scRNA-seq, showing one is dysfunctional and reversible through TNFR2 engagement.

The paper identifies NK cells as key orchestrators of adaptive immune niches in early arthritis by upregulating XCL1, which recruits XCR1+ cDC1s, forming pathogenic modules that correlate with disease severity.

This study uses single-cell RNA sequencing to analyze how hypertrophic burn scars respond to carbon dioxide laser therapy, identifying gene expression patterns and cell types associated with good or poor outcomes.

This study uses spatial transcriptomics to show mitochondrial dysfunction in JDM muscle tissue, independent of interferon-driven inflammation.

This study identifies CD4+ tissue-resident memory Th17 (TRM17) cells as the main source of IL-17A in SpA synovium, showing their role in disease pathology and potential as therapeutic targets.

The paper identifies CSF1 and TGFβ as key signals for synovial lining macrophage development in mice, which occurs postnatally and is monocyte-independent.

The paper uses multi-omic spatial analysis to identify fibroblast subsets in inflamed synovium that create tissue niches influencing immune cell trafficking and inflammation resolution.

This study shows that hapln1b, an ECM component, is required for HSC specification in zebrafish by modulating kit signaling and maintaining ECM integrity.

This study shows that deleting a conserved zebrafish Gata2 enhancer impairs haemogenic endothelium programming and adult haematopoiesis, leading to bone marrow failure and immune defects.