Z. A. Szpiech

Genomic consequences of isolation and inbreeding in an island dingo population

This study analyzes whole-genome sequences of dingoes on an isolated island to assess the genomic impacts of inbreeding and small population size, finding elevated long runs of homozygosity and evidence of purging deleterious mutations.

selscan 2.0: scanning for sweeps in unphased data

selscan 2.0 updates haplotype-based selection statistics for unphased data, enabling analysis without phase information.

The Maintenance of Deleterious Variation in Wild Chinese Rhesus Macaques

This study analyzes whole genomes of wild Chinese rhesus macaques to show inbreeding drives high homozygous deleterious allele burden, while positive selection maintains some deleterious variants.

Genomic signatures of adaptation in native lizards exposed to human-introduced fire ants

This study identifies genomic signatures of adaptation in native lizards exposed to invasive fire ants, showing genetic changes related to immune response and morphology.

A spatially aware likelihood test to detect sweeps from haplotype distributions

This paper introduces a spatially aware likelihood test to detect positive selection by analyzing haplotype frequency distributions and demonstrates its effectiveness on human and rat datasets.

Application of a novel haplotype-based scan for local adaptation to study high-altitude adaptation in rhesus macaques

This paper develops a haplotype-based scan to detect local adaptation and applies it to find high-altitude adaptation in rhesus macaques, identifying 303 genes and EGLN1 as key targets.

Evolution of genes involved in the unusual genitals of the bear macaque, Macaca arctoides

The paper analyzes the evolutionary history and genetic basis of unique genital morphology in the bear macaque, identifying outlier genes associated with genital traits and showing evidence of introgression.

Human demographic history has amplified the effects of background selection across the genome

The paper investigates how non-equilibrium demographic processes amplify background selection effects on genetic diversity in human populations, showing greater diversity loss in non-African populations.